SAFETY, TOLERABILITY, AND DOSE-LIMITING TOXICITY OF LACOSAMIDE IN PATIENTS WITH PAINFUL CHRONIC PANCREATITIS: PROTOCOL FOR A PHASE 1 CLINICAL TRIAL TO DETERMINE SAFETY AND IDENTIFY SIDE EFFECTS

BackgroundChronic abdominal pain is the hallmark symptom of chronic pancreatitis (CP), with 50% to 80% of patients seeking medical attention for pain control.Although several management options are available, outcomes are often disappointing, and opioids remain a mainstay of therapy.Opioid-induced hyperalgesia is a phenomenon resulting in dose esca

Piet Tanks Strauss played an important part in the leadership of the Dutch Reformed Church from 1994 to 2011.This article focuses on important events and the role of the leadership of the Dutch Reformed Church which prepared the way for Strauss and his generation of leaders.It takes the acceptance of the important policy document Church and Society

Business competition has given birth to a facial mask network marketing system or what is commonly referred to as Network Marketing.The utilization used in Network Marketing, or what we currently know as MLM (Multi-Level Marketing), uses a network system where interpersonal communication is required both between MLM members and communication betwee

In 2017, which was held in the Russian Federation under the aegis of the Year of Ecology, its 100th anniversary marked the first Barguzin State Natural Biosphere Ball - Softballs Reserve.Currently, there are 302 specially protected natural areas (PAs) of federal significance in the Russian Federation.There are 105 nature reserves, 55 national parks